منابع مشابه
Experimental rhinovirus infection in volunteers.
Experimental viral disease studies in volunteers have clarified many aspects of the pathogenesis of human viral disease. Recently, interest has focused on rhinovirus-associated asthma exacerbations, and new volunteer studies have suggested that airway responsiveness (AR) is enhanced during a cold. For scientific, ethical and safety reasons, it is important to use validated methods for the prepa...
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Haemophilus ducreyi causes chancroid, which facilitates transmission of human immunodeficiency virus type 1. To better understand the biology of H. ducreyi, we developed a human inoculation model. In the present article, we describe clinical outcomes for 267 volunteers who were infected with H. ducreyi. There was a relationship between papule formation and estimated delivered dose. The outcome ...
متن کاملExperimental Human Rhinovirus Infection
Double-blind trials were conducted in volunteers to evaluate the efficacy of the prophylactic 3,4-dihydro-1-isoquinolineacetamide hydrochloride (DIQA) treatment against rhinovirus type 24 challenge. Ten men received a 7-day course of DIQA treatment and 11 men received a placebo. The intranasal viral challenge dose was 10 mean tissue culture infective doses. The oral administration of 1 g precha...
متن کاملExperimental infection of stray cats with human isolates of Helicobacter pylori
To improve our understanding of Helicobacter infection in cats and to determine whether they are reservoirs for H. pylori and sources of zoonotic transmission to humans, we selected cats as an experimental animal model for gastric colonization by H. pylori. Sixteen stray cats underwent Helicobacter eradication treatment followed by three consecutive oral inoculations of a cocktail of human H...
متن کاملExperimental sodium depletion and salt taste in normal human volunteers.
To examine the sensory effects of extreme sodium depletion in humans, 10 normal volunteers were fed a very-low-sodium diet and were treated with diuretics for 10 d. Urine samples were collected and blood was drawn for hormone analyses. Taste tests included threshold and intensity judgments of salt (NaCl) and sucrose and preferences for salt and sucrose in foods. Subjects also rated the pleasant...
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ژورنال
عنوان ژورنال: The Lancet Infectious Diseases
سال: 2018
ISSN: 1473-3099
DOI: 10.1016/s1473-3099(18)30177-4